Water → HCID 12878147, compound

HRID 980867Notes

Reaction equation

HRID 980867 reaction equation
[CH2:1]([NH:7][CH2:8][C:9]#[N:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH2:11].[OH-].[Na+]>C(O)C>[CH2:1]([NH:7][CH2:8][C:9]([NH2:10])=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 12878154HCID 12878154, compound

Product 1

HCID 12878147HCID 12878147, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In an Erlenmeyer flask of 250 ml, 1 gr (0.072 mol) of n-hexylaminoacetonitrile, 1.22 gr (0.072 mol) of dehydrated cupric chloride and 100 ml of H2O were added. Ethanol was then added until obtention of a homogenous phase. The pH of the solution was adjusted to 10 by means of 1N NaOH and the reaction mixture was stirred for 4 hours at room temperature,; a purple solid was formed and was filtered, resuspended in ammoniac solution and extracted with dichloromethane. The organic phase was three times washed with water, dried on K2CO3 and evaporated. The residue was recrystallized from cyclohexane.

Workup

  1. customa purple solid was formed
  2. filtrationwas filtered
  3. extractionextracted with dichloromethane
  4. washwashed with water
  5. customdried on K2CO3
  6. customevaporated
  7. customThe residue was recrystallized from cyclohexane

Sources & evidence

ORD record
ord-5cc5df7acb6749b2a3268c28046a0509
Source dataset
uspto-grants-1987_01
Patent number
US04639468

Reaction notes

Loading…