反应详情

温度

25 °C

Subsequently, 3.13 g of the 1-benzyl-3-methyl-4-piperidone obtained above was dissolved in 6 ml of ether. The solution was added dropwise to a suspension of 0.44 g of lithium aluminum hydride in 25 ml of ether over 5 minutes while maintaining the temperature at 24°-27° C. Then, the mixture was stirred at 25° C. for 10 minutes, and, 5 ml of water was added thereto under ice-cooling. The mixture was extracted with 30 ml of ether four times. The ether layer was washed with water, dried over anhydrous sodium sulfate and concentrated to obtain 3.17 g of an oily matter of 1-benzyl-4-hydroxy-3-methylpiperidine.

1. temperaturewhile maintaining the temperature at 24°-27° C
2. temperatureunder ice-cooling
3. extractionThe mixture was extracted with 30 ml of ether four times
4. washThe ether layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated