Ethyl orthoformate → HCID 20221218, compound

HRID 980884Notes

Reaction equation

[CH2:1]1[O:12][C:11]2[C:3](=[C:4]([C:8]([N+:13]([O-:15])=[O:14])=[CH:9][CH:10]=2)[C:5]([OH:7])=[O:6])[O:2]1.C(OCC)(OCC)O[CH2:18][CH3:19]>>[CH2:1]1[O:12][C:11]2[C:3](=[C:4]([C:8]([N+:13]([O-:15])=[O:14])=[CH:9][CH:10]=2)[C:5]([O:7][CH2:18][CH3:19])=[O:6])[O:2]1

Participants

Reactant 2

HCID 31214Ethyl orthoformate

HCID 12514101HCID 12514101, compound

Product 1

HCID 20221218HCID 20221218, compoundYield 67%

Procedure

Following the procedure employed in Example 15, condensation of 2,3-methylenedioxy 6-nitrobenzoic acid (10 g) with 40 ml of triethyl orthoformate gives the title compound in 67% yield after ethanol crystallization.

Sources & evidence

ORD record: ord-ffca22802fc14231a72d11b4c3113874
Source dataset: uspto-grants-1987_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04639518

Reaction notes

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