Thionyl Chloride → HCID 13772039, compound

Participants

Reaction Steps

A mixture of 5,6-dimethoxy-3-hydroxyethylquinazolin-2,4-dione (2.0 g, 7.51 mM) and thionyl chloride (0.76 ml, 10.45 mM) in CHCl3 (20 ml) was heated at reflux for 4 hours under nitrogen with vigorous mechanical stirring. Trituration of the solid reaction mixture followed by drying afforded crude product as an off-white solid. The crude product was recrystallized from MeOH (100 ml) and dried to afford the title compound as a white solid; 0.86; (A); mp 118°-120° C.

Provenance & Evidence