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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 980899Generated: October 30, 2026

2-Methyl-2-thiopseudourea → HCID 20221228, compound

https://huagongshe.com/reaction/980899

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2-thiopseudoureaHCID 5142—
ReactantSodium hydrideHCID 24758—
Reactant5-Aminopentan-1-olHCID 75634—
SolventTetrahydrofuranHCID 8028—
ProductHCID 20221228HCID 20221228—

Reaction Steps

S-Methylisothiourea is reacted with 5-aminopentanol and sodium hydride in tetrahydrofuran to give O-(5-aminopentyl)isourea, which is reacted with 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone in refluxing ethanol to give 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04639519
Source datasetuspto-grants-1987_01
ORD IDord-83489d5ae36345d797d5ae818264f629
Source noteuspto-grants-1987_01