HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Ethyl Ketone → HCID 178426619, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Ethyl Ketone | HCID 6569 | — |
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Product | HCID 178426619 | HCID 178426619 | — |
Reaction Steps
Ethyl formate and 2-butanone are added to sodium hydride and cyanoacetamide is added to give 3-cyano-5, 6-dimethyl-2-hydroxypyridine, which is reacted with phosphorus pentachloride and the product reduced with hydrogen and Raney nickel in the presence of semicarbazide, and formaldehyde is added to the mixture to give 2-chloro-5,6-dimethyl-3-pyridinecarboxaldehyde m.p. 69°-70°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04639519 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-dddec9643e67414aa31be32846f517e7 |
| Source note | uspto-grants-1987_01 |