Water → HCID 86741243, compound

Participants

Reaction Conditions

Reaction Steps

1.37 g of acetyl chloride is added to 6.0 g of α-[2-(1-methylethyl)aminoethyl]-α-(2-chlorophenyl)-1-piperidinebutanamide in 100 ml of chloroform and 1.71 g of triethylamine at 0° C. under nitrogen atmosphere. The reaction mixture is stirred at 0° C. for 1 hour, then allowed to warm to room temperature and poured into water. The layers are separated and the organic extract is washed with water and dried over magnesium sulfate. The solvent is removed by evaporation under reduced pressure to provide crude product which is crystallized from ethyl acetate to provide 4.51 g of α-[2-[acetyl(1-methylethyl)amino]ethyl-α-(2-chlorophenyl)-1-piperidinebutanamide having the formula ##STR11##

Provenance & Evidence