HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 2,3,5,6,7,8-Hexahydro-1-methyl-3-oxo-7-(4-pyridinyl)-4-isoquinolinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Acetyl-4-(4-pyridyl)cyclohexanone | HCID 13772055 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,3,5,6,7,8-Hexahydro-1-methyl-3-oxo-7-(4-pyridinyl)-4-isoquinolinecarbonitrile | HCID 13632730 | 34.7% |
Reaction Steps
2-Acetyl-4-(4-pyridyl)cyclohexanone (1.65 g) and cyanoacetamide (0.64 g) were dissolved in ethanol, and a small amount of piperidine was added. The reaction mixture was heated under reflux for 7 hours. After the reaction was completed, deposited crystals were filtered out to obtain 0.7 g of 4-cyano-2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-7-(4-pyridyl)isoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04639521 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-c14929ee32b140db81e84a83b3e6b75d |
| Source note | uspto-grants-1987_01 |