2,3,5,6,7,8-Hexahydro-1-methyl-3-oxo-7-(4-pyridinyl)-4-isoquinolinecarbonitrile → 5,6,7,8-Tetrahydro-1-methyl-7-(4-pyridinyl)-3(2h)-isoquinolinone

Participants

Reaction Steps

4-Cyano-2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-7-(4-pyridyl)isoquinoline (0.5 g) was dissolved in 85% sulfuric acid, and the solution was heated under reflux at 180°-200° C. for 5 hours. After cooling the reaction mixture was poured into ice water. Deposited crystals were filtered out and then purified to obtain 0.38 g of 2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-7-(4-pyridyl)isoquinoline.

Provenance & Evidence