Acetic Anhydride → HCID 14911578, compound

HRID 980915Notes

Reaction equation

HRID 980915 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[C:9](OC(=O)C)(=[O:11])[CH3:10].C([O-])(=O)C.[Na+]>>[C:9]([CH:4]1[CH2:3][CH:2]([CH3:1])[CH2:7][CH2:6][C:5]1=[O:8])(=[O:11])[CH3:10]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 115254-MethylcyclohexanoneHCID 517045Sodium Acetate

Product 1

HCID 14911578HCID 14911578, compound

Procedure

To 24 g of 40% boron trifluoride acetate complex cooled on ice, a mixture of 5.6 g of 4-methylcyclohexanone and 10.5 g of acetic anhydride was dropwise added. The resultant mixture was then stirred at room temperature for 4 hours. To the mixture there was added 50 ml of a saturated aqueous solution of sodium acetate, and then the mixture was heated under reflux for one hour. After cooling, the reaction mixture was extracted with ether to obtain 2-acetyl-4-methylcyclohexanone, which was directly used in the following step without further purifying.

Workup

  1. temperatureTo 24 g of 40% boron trifluoride acetate complex cooled on ice
  2. additionwas dropwise added
  3. temperaturethe mixture was heated
  4. temperatureunder reflux for one hour
  5. temperatureAfter cooling
  6. extractionthe reaction mixture was extracted with ether

Sources & evidence

ORD record
ord-88f36082def64538b515aeaa258238fd
Source dataset
uspto-grants-1987_01
Patent number
US04639521

Reaction notes

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