反应详情

To 24 g of 40% boron trifluoride acetate complex cooled on ice, a mixture of 5.6 g of 4-methylcyclohexanone and 10.5 g of acetic anhydride was dropwise added. The resultant mixture was then stirred at room temperature for 4 hours. To the mixture there was added 50 ml of a saturated aqueous solution of sodium acetate, and then the mixture was heated under reflux for one hour. After cooling, the reaction mixture was extracted with ether to obtain 2-acetyl-4-methylcyclohexanone, which was directly used in the following step without further purifying.

1. temperatureTo 24 g of 40% boron trifluoride acetate complex cooled on ice
2. additionwas dropwise added
3. temperaturethe mixture was heated
4. temperatureunder reflux for one hour
5. temperatureAfter cooling
6. extractionthe reaction mixture was extracted with ether