HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 5-(3-Methoxyphenyl)-1-phenyl-4-(p-toluenesulfonyloxymethyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | o-Toluenesulfonyl chloride | HCID 8623 | — |
| Reactant | 4-Hydroxymethyl-5-(3-methoxyphenyl)-1-phenylpyrrolidin-2-one | HCID 13362003 | — |
| Product | 5-(3-Methoxyphenyl)-1-phenyl-4-(p-toluenesulfonyloxymethyl)pyrrolidin-2-one | HCID 13362004 | — |
Reaction Steps
To 17.2 gm. of 4-hydroxymethyl-5-(3-methoxyphenyl)-1-phenylpyrrolidin-2-one in 35 ml. of dry pyridine was added at 5°-10° 12.2 gm of p toluenesulfonyl chloride over one hour. Workup of the reaction following the procedure given in example 1E provided 17.6 gm of product as a crude oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04639529 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-979a2669d20645ae8f3c999eb27e595f |
| Source note | uspto-grants-1987_01 |