Methanol → HCID 13362026, compound

HRID 980946Notes

Reaction equation

HRID 980946 reaction equation
CO.B(F)(F)F.[CH3:7]COCC.[CH3:12][N:13]1[C:17](=[O:18])[CH2:16][CH:15]([C:19]([OH:21])=[O:20])[CH:14]1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(Cl)(Cl)Cl>[CH3:12][N:13]1[C:17](=[O:18])[CH2:16][CH:15]([C:19]([O:21][CH3:7])=[O:20])[CH:14]1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 8000Boron trifluoride etherateHCID 127355341-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid

Product 1

HCID 13362026HCID 13362026, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 400 ml. of methanol containing 25 ml. of boron trifluoride etherate was added 60 g of 1-methyl-5-oxo-2-phenylpyrrolidin-3-carboxylic acid and the solution refluxed for 8 hours. Concentration in vacuo provided an oil which was dissolved in chloroform. The chloroform solution was washed with a saturated sodium carbonate solution, a saturated sodium bicarbonate solution, water, a saturated sodium chloride solution and dried (Na2SO4). Titration and concentraion in vacuo provided 63 g. of an oil.

Workup

  1. temperaturethe solution refluxed for 8 hours
  2. concentrationConcentration in vacuo
  3. customprovided an oil which
  4. washThe chloroform solution was washed with a saturated sodium carbonate solution
  5. dry with materiala saturated sodium bicarbonate solution, water, a saturated sodium chloride solution and dried (Na2SO4)
  6. customTitration and concentraion in vacuo provided 63 g

Sources & evidence

ORD record
ord-af357196e427478d92774e34d993025e
Source dataset
uspto-grants-1987_01
Patent number
US04639529

Reaction notes

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