Carbon Disulfide → HCID 54489321, compound

Participants

Reaction Steps

Following the procedure of Preparation 9, but using p-nitrobenzyl 2-(3-methoxy-4-methylthio-2-azetidinon-1-yl)-acetate (151 mg), hexamethyldisilazane (185 μl), butyllithium (540 μl), carbon disulphide (26 μl) and bromoacetone (37 μl), there were obtained 121 mg of the desired product, which was a mixture of two isomers. The isomers were isolated by silica gel column chromatography (eluent: a 6:1 by volume mixture of methylene chloride and ethyl acetate).

Provenance & Evidence