HCID 67831590, compound → 2,4-Azetidinedicarboxylic acid, mono(1,1-dimethylethyl) ester, cis-

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Reaction Steps

267 mg (0.7 mmol) of stereochemically pure transor cis-N-benzylazetidine-2,4-dicarboxylic acid benzyl t-butyl ester, 50mg of 10% Pd/C, and 20 ml of methanol are hydrogenated under 3 atm of hydrogen in a Parr shaker for 4 hours. The catalyst is filtered off and thoroughly washed, and the solution evaporated to dryness and dried in vacuo to afford as off-white solids the trans- or cis-azetidine-2,4-dicarboxylic acid mono-t-butyl ester.

Provenance & Evidence