HCID 86744569, compound → HCID 67830825, compound

Participants

Reaction Steps

A solution of cis-N-(benzyloxycarbonyl)azetidine-2,3dicarboxylic acid and, e.g., ammonia are reacted with [(CH3)2N]3PCl2 to form the cis-N-(benzyloxycarbonyl)azetidine-2,3-dicarboxamide (XI), as set forth by Appel et al., Chem. Ber. 116, 2037-2040 (1983). XI, 10% pd/C and methanol are hydrogenated in a Parr shaker under 3 atm of hydrogen, for 4 hours. The catalyst is filtered off and thoroughly washed. The solution is evaporated to dryness and dried in vacuo to arrive at cis-azetidine-2,3-dicarboxamide.

Provenance & Evidence