Acetonitrile → HCID 20071699, compound

Participants

Reaction Steps

The reaction flask was charged with 10 g (0.039 mole) of 4-(sulfonyl)benzenesulfonyl chloride prepared by a procedure described in J. Med. Chem., 6 pp. 307-11 (1963) in 7 ml acetonitrile. A dropping funnel was charged with 8.8 g (0.12 mole) of butylamine and the amine was added dropwise, allowing the temperature to rise. The mixture was stirred for three hours and then concentrated to a thick residue. The residue was slurried with 100 ml water and the mixture filtered to collect a white solid. After drying, the weight of solid was 8.0 g (70% yield), mp 164°-167° C. A recrystallization from 190 proof ethanol (4 ml/g) and water (4 ml/g) gave 6.6 g of title compound, mp 170°-172° C.

Provenance & Evidence