Triethylamine → 1-Benzyl-3-(2-chloroethylamino)pyrrolidine-2,5-dione

Beteiligte Stoffe

Reaktionsschritte

74.8 g (0.4 mol) of N-benzylmaleimide are reacted with 58 g (0.5 mol) of 2-chloroethylamine hydrochloride and 50.5 g (0.5 mol) of triethylamine in accordance with the working instructions of Example Ia. After working up by chromatography, 81.6 g (77% of theory) of an oil with an RF value of 0.24 (on silica gel using ethyl acetate: petroleum ether=1:1) are obtained.

Herkunft & Nachweise