HCID 15069996, compound → Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate

HRID 981107Notes

Reaction equation

HRID 981107 reaction equation
[CH3:1][N:2]1[O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6]2>C(O)C.[Pd]>[OH:9][CH2:8][CH:7]1[CH2:6][N:5]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:4][CH:3]1[NH:2][CH3:1]

Participants

4

Reactant 1

HCID 15069996HCID 15069996, compound

Product 1

HCID 15070021Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10 g (50 mmol) of ethyl 2-methyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate (Example H d)) are hydrogenated in 200 ml of ethanol on 3 g of Pd-on-active charcoal (10% of Pd) at 50° C. under 50 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-2136eb73076e47bfb2e0ba45e9e38621
Source dataset
uspto-grants-1991_02
Patent number
US04990517

Reaction notes

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