HCID 15070022, compound → 2-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane

HRID 981108Notes

Reaction equation

HRID 981108 reaction equation
[CH3:1][N:2]1[CH2:10][O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2>O>[CH3:1][N:2]1[CH2:10][O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Participants

3

Reactant 1

HCID 15070022HCID 15070022, compound

Product 1

HCID 150700232-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9 g (42 mmol) of ethyl 2-methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane-8-carboxylate are heated under reflux with 28 g of Ba(OH)2.8H2O in 280 ml of water overnight. The BaCO3 is filtered off with suction, the filtrate is concentrated and the residue is boiled up with dioxane. The dioxane solution is concentrated and the residue is distilled.

Workup

  1. filtrationThe BaCO3 is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. concentrationThe dioxane solution is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-ad5fa88248d84ff29cf878ee78f097a8
Source dataset
uspto-grants-1991_02
Patent number
US04990517

Reaction notes

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