Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate → (4-(Methylamino)pyrrolidin-3-yl)methanol

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Reaction Steps

34 g (0.168 mol) of ethyl 4-hydroxymethyl-3-methylaminopyrrolidine-1-carboxylate are heated under reflux with 100 g of Ba(OH)2.8H2O in 400 ml of water overnight. The BaCO3 is filtered off with suction, the filtrate is concentrated and the residue is boiled up ten times with 100 ml of dioxane each time. The dioxane solutions are filtered, the filtrate is concentrated and the residue is distilled.

Provenance & Evidence