反应详情

6.0 g (22 mmol) of 1-benzoyl-trans-3-ethylamino-4-methylthio-pyrrolidine are stirred vigorously with 22 ml of 5N NaOH at 100° C. for 24 hours, until the conversion is homogeneous. The mixture is then extracted with 3×80 ml of ether and the extract is dried over sodium sulphate and concentrated on a rotary evaporator. The crude product is distilled through a micro-puncture column.

1. extractionThe mixture is then extracted with 3×80 ml of ether
2. dry with materialthe extract is dried over sodium sulphate
3. concentrationconcentrated on a rotary evaporator
4. distillationThe crude product is distilled through a micro-puncture column