1,6-Dibromohexane → HCID 13536971, compound

Participants

Reaction Steps

2-(Methylthio)benzeneethanol (2.0 g) and 1,6-dibromohexane (9.31 g) were stirred rapidly at room temperature with tetrabutylammonium bisulphate (0.34 g) and 12.5 M aqueous sodium hydroxide (11 ml) for 16 h. The mixture was diluted with water (45 ml), extracted with ER (3×55 ml) and the combined organic extracts were washed consecutively with water (45 ml) and brine (45 ml), dried and evaporated. The residual oil (8.84 g) was purified by [FCS] using ER-cyclohexane (0:100→2:98) as eluent to give the title compound. T.l.c. (Cyclohexane--ER, 79:1) Rf 0.17.

Provenance & Evidence