Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 86744573, compound

Participants

Reaction Steps

A solution of 4-(diethylamino) benzaldehyde (10 g) and carbomethoxymethylenetriphenylphosphorane (20 g) in dry acetonitrile (100 ml) was stirred at reflux under nitrogen for 24 h. The solvent was evaporated and the residual oil was treated with ER (100 ml). The precipitate was filtered, the filtrate was concentrated to an oil and the ER treatment was repeated. After filtration and evaporation the resulting orange oil was purified by [FCS] eluting with cyclohexane/EA/triethylamine 80:20:1) to give the title compound (10.0 g). T.l.c. (cyclohexane/EA/triethylamine 80:20:1) Rf 0.33.

Provenance & Evidence