4-Iodoaniline → HCID 13537038, compound

Participants

Reaction Steps

Butanesulphonyl chloride (7.8 g) was added dropwise to a stirred solution of 4-iodobenzeneamine (10 g) in pyridine (50 ml) at 0°, the mixture was stirred at room temperature for 1 h, concentrated, and partitioned between 2 N hydrochloric acid (100 ml) and EA (100 ml). The organic layer was washed with 2 N hydrochloric acid, water and brine, dried and concentrated to a solid which was recrystallised from cyclohexane to give the title compound (10.5 g) m.p. 80°-81°.

Provenance & Evidence