HCID 10020712, compound → HCID 14051004, compound

HRID 981163Notes

Reaction equation

HRID 981163 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:13]=[N:12][C:11]=2[C:22]([O:24]CC)=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH3:27].CO>C(Cl)Cl>[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[C:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:13]=[N:12][C:11]=2[C:22]([NH2:27])=[O:24])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 10020712HCID 10020712, compoundHCID 21705897Ammonia methanol

Product 1

HCID 14051004HCID 14051004, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of ethyl 4-(3-nitrophenyl)-6-phenyl-3-pyridazinecarboxylate (1 g) in methylene chloride (10 ml) was added ammonia-methanol solution (60 ml) which was prepared by bubbling an ammonia gas (14 g) into methanol (120 ml), and the mixture was stirred for hours at ambient temperature. After evaporating the solvent, the residue was recrystallized from methanol to give 4-(3-nitrophenyl)-6-phenyl-3-p-yridazinecarboxamide (0.78 g).

Workup

  1. customwas prepared
  2. customby bubbling an ammonia gas (14 g) into methanol (120 ml)
  3. customAfter evaporating the solvent
  4. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-d6e7c3bef8d747fda9531a8a135cfe97
Source dataset
uspto-grants-1991_02
Patent number
US04990507

Reaction notes

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