Diketene → N-(2-morpholin-4-ylethyl)-3-oxobutanamide

Beteiligte Stoffe

Reaktionsschritte

To a solution of diketene (23.0 ml) in diethyl ether (115 ml) was added dropwise a solution of N-(2-aminoethyl)morpholine (34.7 g) in diethyl ether (300 ml) at -40° C. After stirring for 2 hours at the same condition, the resulting precipitates were collected by filtration and dried in vacuo to give N-(2-morpholinoethyl)acetoacetamide (41.1 g, yield 72.0 %).

Herkunft & Nachweise