HCID 20071616, compound → HCID 20071618, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5.75 g of 8-chloro-3-ethoxycarbonyl-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine in 60 cm3 of 17.5% hydrochloric acid is heated, with stirring, at a temperature close to 100° C. for 30 minutes. After cooling to about 20° C., the insoluble matter is drained and washed with 3 times 20 cm3 of ethanol and 3 times 20 cm3 of diethyl ether. 3.05 g of 8-chloro-7-fluoro- 4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid are obtained in the form of a beige solid which decomposes at 416° C.

Provenance & Evidence