HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → HCID 67927954, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 8-Chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid | HCID 14700554 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 14700560 | HCID 14700560 | — |
| Product | HCID 67927954 | HCID 67927954 | 92.3% |
Reaction Steps
7-Fluoro-1-methyl-4-oxo-8-(1-piperazinyl)-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid is prepared under the conditions of Reference Example 1 but starting from 10 g of 8-chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid and 28 g of piperazine in 100 cm3 of pyridine. 5.5 g of 7-fluoro-1-methyl-4-oxo-8-(1-piperazinyl)-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid hemihydrate are obtained in the form of a yellow solid melting at 370°-375° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04990515 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-33030f12d1cb4d7c8c5da943377c8000 |
| Source note | uspto-grants-1991_02 |