HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethylpiperazine → HCID 67925873, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethylpiperazine | HCID 66056 | — |
| Reactant | 8-Chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid | HCID 14700554 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 14700564 | HCID 14700564 | — |
| Product | HCID 67925873 | HCID 67925873 | 100.9% |
Reaction Steps
8-(3,5-Dimethyl-1-piperazinyl)-7-fluoro-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid is prepared under the conditions of Reference Example 3 but starting from 1.7 g of 8-chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid and 2.5 g of 2,6-dimethylpiperazine in 20 cm3 of pyridine. 1.1 g of 8-(3,5-dimethyl-1-piperazinyl)-7-fluoro-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid hemihydrate are obtained in the form of a yellow solid melting at 294°-295° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04990515 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-eb8893dbbbba4bb5a9cbdfcf7bf1b75e |
| Source note | uspto-grants-1991_02 |