Methyl 4-(1-carboxyvinyl)-2,3,5,6-tetrafluorobenzoate → Methyl 2,3,5,6-tetrafluoro-4-vinylbenzoate

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Reaction Steps

In 20 ml of N,N-dimethylformamide was dissolved 3.0 g of methyl 4-(1-carboxyvinyl)-2,3,5,6-tetrafluorobenzoate. The resulting solution was stirred at 130°-140° C. for 1.5 hours. The reaction mixture was concentrated under reduced pressure. The residue obtained was purified by a column chromatography (eluant: toluene/n-hexane=1/1) to obtain 2.0 g (yield: 79.1%) of methyl 2,3,5,6-tetrafluoro-4-vinylbenzoate.

Provenance & Evidence