2-Aminopropanol → HCID 178472009, compound

Participants

Reaction Steps

In 30 ml of benzene was dissolved 3.00 g of ethyl 4-(1-benzyloxycarbonylaminocyclopropyl)- 2,3,5-trifluorobenzoylacetate. To the resulting solution was added 3.69 g of N,N-dimethylformamide-dimethylacetal. The resulting mixture was refluxed for 30 minutes. The reaction mixture was concentrated under reduced pressure. The residue obtained was dissolved in 15 ml of toluene. To the resulting solution was added 518 mg of DL-2-amino-1-propanol. The resulting mixture was stirred at room temperature for 17 hours. The reaction mixture was concentrated under reduced pressure. The residue obtained was purified by a column chromatography (eluant: toluene/ethyl acetate=5/1) to obtain 3.09 g (yield: 86.1%) of ethyl 2-[4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5trifluorobenzoyl]-3-(2-hydroxy-1-methylethylamino)acrylate.

Provenance & Evidence