Trifluoroacetic acid → HCID 54166271, compound

Participants

Reaction Steps

To 2 ml of trifluoroacetic acid was added, with ice-cooling, 300 mg of ethyl (S)-7-(1-benzyloxycarbonylaminocyclopropyl)-6,8-difluoro-1-[2-(N-tert-butoxycarbonyl-N-methylamino)-1-methylethyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylate. The resulting mixture was stirred at the same temperature for 2.5 hours. The reaction mixture was concentrated under reduced pressure. To the residue obtained were added 20 ml of ethyl acetate and 10 ml of water in this order. The resulting mixture was adjusted to pH 8 with a saturated aqueous sodium hydrogencarbonate solution. The organic layer was separated, washed with water and a saturated aqueous sodium chloride solution in this order, and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to obtain 240 mg (yield: 96.0%) of ethyl (S)-7-(1-benzyloxycarbonylaminocyclopropyl)-6,8-difluoro-1-[2-(N-methylamino)-1methylethyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylate.

Provenance & Evidence