Trifluoroacetic acid → HCID 86744592, compound

Participants

Reaction Steps

5 ml of trifluoroacetic acid was added to 570 mg of ethyl (S)-10-(2-tert-butoxycarbonylcyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate. The resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure. Diethyl ether was added to the residue obtained. The resulting crystals were collected by filtration to obtain 460 mg (yield: 92.9%) of ethyl (S)-10-(2-carboxycyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate.

Provenance & Evidence