HCID 20071502, compound → HCID 15136279, compound

Participants

Reaction Steps

In 5 ml of acetic acid was dissolved 50 mg of 8-benzylamino-10-cyclopropyl-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid. To the resulting solution was added 50 mg of 5% palladium-carbon. The resulting mixture was stirred at room temperature for 1.5 hours at atmospheric pressure in a hydrogen stream. The reaction mixture was filtered. The filtrate was concentrated to dryness under reduced pressure. Ethanol was added to the residue obtained. The resulting crystals were collected by filtration to obtain 19.7 mg (yield: 50.5%) of 8-amino-10-cyclopropyl9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid. Melting point: >280° C. (recrystallized from chloroform-ethanol)

Provenance & Evidence