HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 5-Chloro-6-hydroxynicotinoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178524771 | HCID 178524771 | — |
| Product | 5-Chloro-6-hydroxynicotinoyl chloride | HCID 178521127 | — |
Reaction Steps
6.3 g (36 mmol) of 5-chloro-6-hydroxynicotinic acid are heated under reflux in 60 ml of thionyl chloride for 4 hours. After the volatile constituents have been stripped off, 50 ml of toluene are added and the mixture is evaporated again. Colorless crystals, yield 6.9 g (quantitative), melting point: >250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04990620 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-6f7458d9bbc342a6819a8b6c924a1d01 |
| Source note | uspto-grants-1991_02 |