1-Benzylpiperazine → HCID 18643652, compound

HRID 981390Notes

Reaction equation

HRID 981390 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:15]([OH:17])=O)[CH2:10][CH2:11][C:12](=[O:14])[NH2:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:18]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:1]([O:5][C:6]([NH:8][C@H:9]([C:15]([N:28]1[CH2:29][CH2:30][N:25]([CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:26][CH2:27]1)=[O:17])[CH2:10][CH2:11][C:12](=[O:14])[NH2:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 83687L-Glutamine, N2-((1,1-dimethylethoxy)carbonyl)-

Product 1

HCID 18643652HCID 18643652, compoundYield 85.6%

Procedure

In the same manner as in Reference Example 2, N-tert-butoxycarbonyl-L-glutamine (8.0 g) and 1-benzylpiperazine (5.7 g) were condensed to obtain a colorless crystal 1-(N-tert-butoxycarbonyl-L-glutaminyl)-4-benzylpiperazine (11.2 g).

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-51982bce6f1c4c96ab30946cbbea8cd2
Source dataset
uspto-grants-1991_02
Patent number
US04990614

Reaction notes

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