HCID 9840634, compound → HCID 18643642, compound

HRID 981396Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:29])[C@H:15]([CH2:24][CH2:25][C:26](=[O:28])[NH2:27])[NH:16][C:17](OC(C)(C)C)=[O:18])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:30]([O:37][C:38]1[CH:46]=[C:45]([O:47][CH2:48][C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[CH:44]=[CH:43][C:39]=1C(O)=O)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:29])[C@H:15]([CH2:24][CH2:25][C:26](=[O:28])[NH2:27])[NH:16][C:17](=[O:18])[C:44]2[CH:43]=[CH:39][C:38]([O:37][CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[CH:46][C:45]=2[O:47][CH2:48][C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 9840634HCID 9840634, compound

HCID 18643652HCID 18643652, compound

Product 1

HCID 18643642HCID 18643642, compoundYield 26.9%

Procedure

Condensation of 1-benzyl-4-(N-tert-butoxycarbonyl-L-glutaminyl)piperazine (1.0 g) and 2,4-dibenzyloxybenzoic acid (752 mg) was carried out in the same manner as in Example 7 (i) to obtain colorless crystalline powder 1-benzyl-4-(2,4-dibenzyloxybenzoyl-L-glutaminyl)piperazine (375 mg). Melting point: 133°-135° C.

Sources & evidence

ORD record: ord-91aacc207d3c467b92a2f920e0bbe71e
Source dataset: uspto-grants-1991_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04990614

Reaction notes

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