HCID 18643645, compound → HCID 18643610, compound

HRID 981397Notes

Reaction equation

HRID 981397 reaction equation
[ClH:1].C([N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:33])[C@H:16]([CH2:28][CH2:29][C:30](=[O:32])[NH2:31])[NH:17][C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][C:20]=2[OH:26])[CH2:11][CH2:10]1)C1C=CC=CC=1>[C].[Pd]>[ClH:1].[OH:26][C:20]1[CH:21]=[C:22]([OH:25])[CH:23]=[CH:24][C:19]=1[C:18]([NH:17][C@H:16]([C:15]([N:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1)=[O:33])[CH2:28][CH2:29][C:30](=[O:32])[NH2:31])=[O:27]

Participants

3

Reactant 1

HCID 18643645HCID 18643645, compound

Product 1

HCID 18643610HCID 18643610, compoundYield 81.8%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

10% Palladium-carbon (150 mg) was added to an ethanolic solution (15 ml) of 1-benzyl-4-(2,4-dihydroxybenzoyl-L-glutaminyl)piperazine.hydrochloride (276 mg) obtained in Example 8 (ii) and catalytic reduction was carried out in the same manner as in Example 6 to obtain colorless powder 1-(2,4-dihydroxybenzoyl-L-glutaminyl)piperazine.hydrochloride (183 mg).

Sources & evidence

ORD record
ord-edae9cebc4dd4f6ba7416fc01c973649
Source dataset
uspto-grants-1991_02
Patent number
US04990614

Reaction notes

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