HCID 18643595, compound → HCID 18643608, compound

HRID 981398Notes

Reaction equation

HRID 981398 reaction equation
[ClH:1].C([O:9][C:10]1[CH:33]=[C:32]([O:34]CC2C=CC=CC=2)[CH:31]=[CH:30][C:11]=1[C:12]([NH:14][C@H:15]([C:21]([N:23]1[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]1)=[O:22])[CH2:16][CH2:17][C:18](=[O:20])[NH2:19])=[O:13])C1C=CC=CC=1>[H][H].[C].[Pd]>[ClH:1].[OH:9][C:10]1[CH:33]=[C:32]([OH:34])[CH:31]=[CH:30][C:11]=1[C:12]([NH:14][C@H:15]([C:21]([N:23]1[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]1)=[O:22])[CH2:16][CH2:17][C:18](=[O:20])[NH2:19])=[O:13]

Participants

4

Reactant 1

HCID 18643595HCID 18643595, compound

Product 1

HCID 18643608HCID 18643608, compoundYield 85.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 178418361HCID 178418361, compoundSolvent

Procedure

10% Palladium-carbon (200 mg) was added to an ethanolic solution (50 ml) of 1-(2,4-dibenzyloxybenzoyl-L-glutaminyl)-4-methylpiperazine.hydrochloride (270 mg) obtained above and catalytic reduction was carried out at room temperature and under atmospheric pressure in hydrogen stream. Thereafter, treatments were conducted in the same manner as in Example 5 (ii) to obtain colorless crystalline powder 1-(2,4-dihydroxybenzoyl-L-glutaminyl)-4-methylpiperazine.hydrochloride (160 mg). Melting point: 144°-145° C.

Workup

  1. customobtained above and catalytic reduction

Sources & evidence

ORD record
ord-7dd1a09146f941a0b2e95ebcf077279c
Source dataset
uspto-grants-1991_02
Patent number
US04990614

Reaction notes

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