HCID 10594810, compound → HCID 54462335, compound

HRID 981400Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[CH2:23][CH2:24][C:25](O)=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:28]([N:35]1[CH2:40][CH2:39][N:38]([C:41](=[O:56])[C@H:42]([CH2:51][CH2:52][C:53](=[O:55])[NH2:54])[NH:43]C(OC(C)(C)C)=O)[CH2:37][CH2:36]1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:12]=[CH:11][C:10]=1[CH2:23][CH2:24][C:25]([NH:43][C@H:42]([C:41]([N:38]1[CH2:37][CH2:36][N:35]([CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:40][CH2:39]1)=[O:56])[CH2:51][CH2:52][C:53](=[O:55])[NH2:54])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 10594810HCID 10594810, compound

HCID 18643652HCID 18643652, compound

Product 1

HCID 54462335HCID 54462335, compoundYield 89.6%

Procedure

Condensation of 3-(2,4-dibenzyloxyphenyl) propionic acid (748 mg) and 1-benzyl-4-(N-tert-butoxycarbonyl-L-glutaminyl)piperazine (1.0 g) was effected in the same manner as in Example 8 (i) to obtain colorless crystalline powder 1-[3-(2,4-dibenzyloxyphenyl)propionyl-L-glutaminyl]-4-benzylpiperazine (1.20 g). Melting point: 145°-147° C.

Sources & evidence

ORD record: ord-df41a3e9725b43beae594b68ccf4c0d2
Source dataset: uspto-grants-1991_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04990614

Reaction notes

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