HCID 10594810, compound → HCID 53868534, compound

HRID 981401Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[CH2:23][CH2:24][C:25]([OH:27])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC([NH:35][C@H:36]([C:41]([N:43]1[CH2:48][CH2:47][N:46]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[CH2:45][CH2:44]1)=[O:42])[CH2:37][C:38](=[O:40])[NH2:39])=O)(C)(C)C>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:12]=[CH:11][C:10]=1[CH2:23][CH2:24][C:25]([NH:35][C@H:36]([C:41]([N:43]1[CH2:44][CH2:45][N:46]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[CH2:47][CH2:48]1)=[O:42])[CH2:37][C:38](=[O:40])[NH2:39])=[O:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 10594810HCID 10594810, compound

HCID 18643655HCID 18643655, compound

Product 1

HCID 53868534HCID 53868534, compoundYield 32.5%

Procedure

Condensation of 3-(2,4-dibenzyloxyphenyl)propionic acid (772 mg) and 1-(N-tert-butoxycarbonyl-L-asparaginyl)-4-phenylpiperazine (964 mg) was carried out in the same manner as in Example 7 (i) to obtain colorless crystal 1-[3-(2,4-dibenzyloxyphenyl)propionyl-L-asparaginyl]- 4-phenylpiperazine (430 mg). Melting point: 96°-98° C.

Sources & evidence

ORD record: ord-a40bb8224c4d431380d8b7a4240a1f44
Source dataset: uspto-grants-1991_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04990614

Reaction notes

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