2-[2,4-Bis(benzyloxy)phenyl]acetic Acid → HCID 18643603, compound

HRID 981402Notes

Reaction equation

HRID 981402 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)C=[CH:11][C:10]=1CC(O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O[C:32]([NH:34][C@H:35]([C:40]([N:42]1[CH2:47][CH2:46][N:45]([CH3:48])[CH2:44][CH2:43]1)=[O:41])[CH2:36][C:37](=[O:39])[NH2:38])=O)(C)(C)C>>[CH2:16]([O:15][C:13]1[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=[CH:11][C:32]=1[NH:34][C@H:35]([C:40]([N:42]1[CH2:43][CH2:44][N:45]([CH3:48])[CH2:46][CH2:47]1)=[O:41])[CH2:36][C:37](=[O:39])[NH2:38])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 50283782-[2,4-Bis(benzyloxy)phenyl]acetic AcidHCID 18643654HCID 18643654, compound

Product 1

HCID 18643603HCID 18643603, compoundYield 88.6%

Procedure

Condensation of 2,4-dibenzyloxyphenylacetic acid (923 mg) and 1-(N-tert-butoxycarbonyl-L-asparaginyl)-4-methylpiperazine (1.0 g) was carried out in the same manner as in Example 12 (i) to obtain colorless crystalline powder 1-(2,4-dibenzyloxyphenyl-L-asparaginyl)-4-methylpiperazine (1.18 g). Melting point: 83°-85° C.

Sources & evidence

ORD record
ord-673039e648fb45ac9ea0e13863c56288
Source dataset
uspto-grants-1991_02
Patent number
US04990614

Reaction notes

Loading…