p-Fluorophenyl 4-piperidyl ketone hydrochloride → HCID 20071588, compound

HRID 981410Notes

Reaction equation

HRID 981410 reaction equation
Cl.[F:2][C:3]1[CH:16]=[CH:15][C:6]([C:7]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:8])=[CH:5][CH:4]=1.[CH2:17]([O:24][C:25]1[CH:30]=[C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:28]=[CH:27][C:26]=1[CH2:39][CH2:40][C:41](O)=[O:42])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([O:24][C:25]1[CH:30]=[C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:28]=[CH:27][C:26]=1[CH2:39][CH2:40][C:41]([N:12]1[CH2:13][CH2:14][CH:9]([C:7](=[O:8])[C:6]2[CH:5]=[CH:4][C:3]([F:2])=[CH:16][CH:15]=2)[CH2:10][CH2:11]1)=[O:42])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 3084438p-Fluorophenyl 4-piperidyl ketone hydrochlorideHCID 10594810HCID 10594810, compound

Product 1

HCID 20071588HCID 20071588, compoundYield 77.7%

Procedure

Condensation between 4-(4-fluorobenzoyl) piperidine.hydrochloride (682 mg) and 3-(2,4-dibenzyloxyphenyl)propionic acid (1.04 g) is carried out in the same manner as in Example 1, (i) to yield 1-[3-(2,4-dibenzyloxyphenyl)propionyl]-4-(4-fluorobenzoyl)piperidine (1.20 g) in the colorless columnar crystal form.

Sources & evidence

ORD record
ord-a07ab6f24aea476885d6e8d6aa46a058
Source dataset
uspto-grants-1991_02
Patent number
US04990511

Reaction notes

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