HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 20071578, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | Diethyl cyanophosphonate | HCID 76257 | — |
| Reactant | 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid | HCID 5028378 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 20071578 | HCID 20071578 | 87.6% |
Reaction Steps
To solution (15 ml) of 2,4-dibenzyloxyphenyl acetic acid (760 mg) and 1-benzylpiperazine (440 mg) in N,N-dimethylformamide are added triethylamine (0.6 ml) and diethyl cyanophosphate (420 mg) at 5° C. under stirring and stirring is continued for 15 minutes. To the reaction solution is added water and the product is extracted with dichloromethane. The dichloromethane layer is washed with water and dried. The solvent is distilled off to yield 1-(2,4-dibenzyloxyphenylacetyl)-4-benzylpiperazine (968 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04990511 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-ed42610e45004ab39ad07c5752f9dc22 |
| Source note | uspto-grants-1991_02 |