Diethyl Ether → HCID 20071589, compound

Participants

Reaction Steps

To a solution (10 ml) of 1-(2,4-dihydroxyphenyl-acetyl)-4-benzylpiperazine.hydrochloride (160 mg) obtained in Example 9, ii) in ethanol is added palladium-black (30 mg) to subject to catalytic reduction in hydrogen at 40° C. under twice atmospheric pressure for 10 hours. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure. The glass-like substance obtained is digested with ether into powder. This is filtered and dried to obtain 1-(2,4-dihydroxyphenylacetyl)piperazine.hydrochloride (147 mg).

Provenance & Evidence