反应详情

A mixture of 4.5 g of phenylguanidine nitrate, 3.3 g of methoxyacetylacetone and 12 g of anhydrous sodium carbonate was heated with stirring and allowed to react at 150° C. for 2 hours. After cooling to room temperature, water was added to the reaction mixture, which was then extracted with 150 ml of toluene. The toluene layer was washed with water, dried over Glauber's salt and concentrated by evaporation under reduced pressure. The residue was purified by silica gel column chromatography to obtain 3.5 g (yield: 68%) of 2-anilino-4-methoxymethyl-6-methylpyrimidine.

1. temperaturewas heated
2. customto react at 150° C. for 2 hours
3. extractionwas then extracted with 150 ml of toluene
4. washThe toluene layer was washed with water
5. dry with materialdried over Glauber's salt
6. concentrationconcentrated by evaporation under reduced pressure
7. customThe residue was purified by silica gel column chromatography