反应详情

Boron bromide (3.9 g) was added dropwise to a solution of 3.0 g of 2-anilino-4-methoxymethyl-6-methylpyrimidine in 100 ml of dichloromethane at -70° C. After completion of the dropwise addition, the coolant was removed and the mixture was stirred at room temperature for 5 hours. The reaction mixture was poured into water gradually. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The solid residue was recrystallized from ethanol-hexane to obtain 2.5 g (yield: 89%) of 2-anilino-4-hydroxymethyl-6-methyl-pyrimidine having a melting point of 118°-120° C.

1. additionAfter completion of the dropwise addition
2. customthe coolant was removed
3. additionThe reaction mixture was poured into water gradually
4. washThe organic layer was washed with water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. customThe solid residue was recrystallized from ethanol-hexane