HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → Cis-7-[(2-Aminocyclopentyl)amino]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 800521 | — |
| Reactant | cis-Cyclopentane-1,2-diamine | HCID 11412654 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Cis-7-[(2-Aminocyclopentyl)amino]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 54518842 | 63.3% |
Reaction Steps
The procedure of Example 1 was followed using 0.6 g of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid and 1.0 g of cis-1,2-cyclopentanediamine in 4 ml of pyridine, giving 0.5 g of the desired product, m.p. 233°-235° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04992449 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-65bb6dc8a70a4652a49121afe397f6c4 |
| Source note | uspto-grants-1991_02 |