HCID 423072, compound → HCID 15124164, compound

HRID 981511Notes

Reaction equation

HRID 981511 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:14])=[C:10](F)[CH:11]=2)[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2].[NH2:19][CH:20]1[CH2:23][CH2:22][CH:21]1[NH2:24]>N1C=CC=CC=1>[NH2:19][CH:20]1[CH2:23][CH2:22][CH:21]1[NH:24][C:10]1[CH:11]=[C:12]2[C:7]([C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4][N:3]2[CH2:1][CH3:2])=[CH:8][C:9]=1[F:14]

Participants

4

Reactant 2

HCID 423072HCID 423072, compoundHCID 8005211-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 15124164HCID 15124164, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid and 1,2 diaminocyclobutane [The American Chemical Society, Vol. 64, p. 2696 (1942)] in pyridine is reacted as described in Example 1 giving the desired product.

Sources & evidence

ORD record
ord-7edc920bc1044f0da00a27911e658f9b
Source dataset
uspto-grants-1991_02
Patent number
US04992449

Reaction notes

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