HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzaldehyde → 4-(2-Chlorophenyl)-3-ethoxycarbonyl-6,6-dimethyl-2-[2-(2-methylbenzimidazol-1-yl)ethoxymethyl]-1,4,5,6,7,8-hexahydro-5-oxoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzaldehyde | HCID 6996 | — |
| Reactant | 3-Amino-6,6-dimethylcyclohex-2-en-1-one | HCID 18187175 | — |
| Reactant | Ethyl 4-[2-(2-methylbenzimidazol-1-yl)ethoxy]-3-oxobutanoate | HCID 20070378 | — |
| Product | 4-(2-Chlorophenyl)-3-ethoxycarbonyl-6,6-dimethyl-2-[2-(2-methylbenzimidazol-1-yl)ethoxymethyl]-1,4,5,6,7,8-hexahydro-5-oxoquinoline | HCID 20070376 | 11.5% |
Reaction Steps
The title compound (63 mg) was prepared from 2-chlorobenzaldehyde (202 mg), 3-amino-6,6-dimethyl-2-cyclohexene-1-one (200 mg) and ethyl 4-[2-(2-methylbenzimidazol-1-yl)ethoxy]-3-oxobutanoate (304 mg) by the method of Example 1. M.p. 118°-120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04992447 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-f46ec38a5fb94fe99351ec4be23b207b |
| Source note | uspto-grants-1991_02 |